Discriminative structural approaches for enzyme active-site prediction
نویسندگان
چکیده
منابع مشابه
Active site prediction using evolutionary and structural information
MOTIVATION The identification of catalytic residues is a key step in understanding the function of enzymes. While a variety of computational methods have been developed for this task, accuracies have remained fairly low. The best existing method exploits information from sequence and structure to achieve a precision (the fraction of predicted catalytic residues that are catalytic) of 18.5% at a...
متن کاملMetric learning for enzyme active-site search
MOTIVATION Finding functionally analogous enzymes based on the local structures of active sites is an important problem. Conventional methods use templates of local structures to search for analogous sites, but their performance depends on the selection of atoms for inclusion in the templates. RESULTS The automatic selection of atoms so that site matches can be discriminated from mismatches. ...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2011
ISSN: 1471-2105
DOI: 10.1186/1471-2105-12-s1-s49